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Metformin-Induced Vitamin B12 Deficiency in Patients With Type-2 Diabetes Mellitus - PMC

Subsequent research confirmed that gp91phox, a key subunit of NOX2, promotes microglial activation, neuroinflammation, and ferroptosis, contributing to cognitive deficits in PD mice—suggesting that targeting gp91phox may offer a promising therapeutic strategy (Tian et al., 2024)

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Vitamin D receptors and metabolizing enzymes have been identified in male reproductive tissues, suggesting its local action in spermatogenesis and sperm maturation