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[DOI] [PubMed] [Google Scholar] 49.Kinlay S., Behrendt D., Fang J.C., Delagrange D., Morrow J., Witztum J.L., Rifai N., Selwyn A.P., Creager M.A., Ganz P

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High levels of S1P in fact have been found in the peritoneal environment of women suffering of endometriosis, showing the capability to induce differentiation of macrophages into CD163 + M2 type, which secretes pro-inflammatory cytokines such as IL-6, COX-2, and TGF-β contributing to the inflammation and fibrosis underlying these lesions [45]