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Moreover, elevated concentration of extracellular glutamate is considered not only a main reason for the degeneration of neurons and/or cell death as observed in neurodegenerative diseases, but is also a risk factor for mood/anxiety disorders like depression (de Kloet et al., Elevated levels of glutamate in the brain can inhibit the synthesis of intracellular glutathione independently of the NMDA receptor activation status (Breyer et al., in vivo study using a chronic stress rat model of depression (Grundmann et al., in vitro or in vivo experimental systems (Raso et al., Furthermore, it has been reported that four constituents of H
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