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Under physiological conditions, Nrf2 translocates from the cytoplasm to the nucleus upon oxidative challenge, binding to ARE sequences to induce expression of protective genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase catalytic subunit (GCLC) (Xu et al., 2023

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However, a few studies have suggested that these actions of the trefoil peptides may also contribute to the movement of cancer cells, known as metastasis, in cell models