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Healthy mitochondrial function is vital for healthy aging.5

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The mRNA levels of cytoprotective genes, including sulfiredoxin-1, glutamate-cysteine ligase, and glutathione peroxidase-2 were expressed only in Nrf2-enhanced mice, suggesting that Nrf2 activation prevents oxidative stress and acute liver injury through modulation of antioxidant defense-associated genes (Figure 1)