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Techniques that have been used in treating EDS pain include manual therapy for overactive muscles, trunk stabilization, posture re-education, joint awareness using biofeedback, and joint mobilization with muscle release

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Iron loading anemia, such as beta-thalassemia and sickle cell disease, is commonly treated with blood transfusion combined with measures to prevent iron overload or allogeneic hematopoietic stem cell transplantation (HSCT) [34]