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No increases in ROS levels or DNA damage were observed in the GPX3 knock-out mice prior to carcinogen treatment, suggesting that GPx3 loss primarily contributes to carcinogenesis in the context of exogenous stress [103]

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In its announcement of the seed money, the company, Elevian, said its goal was to develop “new medicines” that increase the activity levels of the hormone GDF11 “to potentially prevent and treat age-related diseases.” It described research by its founders, which include Harvard’s Amy Wagers and Richard Lee, as demonstrating that “replenishing a single circulating factor, GDF11, in old animals mirrors the effects of young blood, repairing the heart, brain, muscle and other tissues.” Other respected labs in the field have either failed to replicate or contradict key elements of their observations