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As proof of concept that endosomal maturation inhibitors have clinical potential, CQ and hydroxy-CQ (HCQ), lysosomotropic agents that block endosomal acidification, are used to treat SLE 49 , RA 50 and, to a lesser extent, sJIA 51
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The higher number of amino acid groups and the unique steric chain structure allow LAAM GSH-CQDs to interact more effectively with water molecules via hydrogen bonding, creating a hexagonal arrangement and resulting in chair-form hexamer hydration layers, leading to improved solubility and stability