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NAD+ is a direct substrate replenishing cellular pools (low oral bioavailability), whereas 5-Amino-1MQ is an NNMT enzyme inhibitor protecting existing NAD+ from degradation

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One study found that it’s okay if the activated charcoal is taken at least three hours after or twelve hours before you take the pill [20], but it’s best to use a backup method if you need to take activated charcoal while you’re on the pill to be sure