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Although some clinical trials are in progress, due to severe side effects such as those caused by an undesired pharmacological activity, suppression of the innate immune response to viral and bacterial infections, and damage to the central nervous system and liver, 244,245 these drugs remain challenging for a clinical application

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Several compounds have shown telomerase-activating properties including TA-65 (derived from astragalus), cycloastragenol, and various supplements