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It is a once-weekly subcutaneous injection that simultaneously activates two incretin hormone pathways — GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) — producing combined metabolic effects that exceed single-agonist drugs like semaglutide

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Gln synthesis in the central nervous system is largely confined to astrocytes (the site of glutamine synthetase activity) (Martinez-Hernandez et al., 1977)