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During the past 15 years, it has become clear that administration of folic acid in doses of 1–5 mg per day helps to prevent much of the toxicity of methotrexate without interfering with the anti-inflammatory efficacy of the drug, whereas very high doses of folinic acid also prevent methotrexate toxicity but may interfere with its efficacy [7-20]

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"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials"