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once constructed three different tumor models in mice by using 7,12‐dimethylbenz(a)anthracene (DMBA), (±)‐(E)‐4‐methyl‐2‐[(E)‐hydroxyamino]‐5‐nitro‐6‐methoxy‐3‐hexanamide (NOR‐1) and TPA, N ‐nitrosodiethylamine (DEN) and phenobarbital, respectively (Kapadia et al., 2003)