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in vitro , indicating that heightened levels of AT2, coupled with reduced deacetylase levels, may exert synergistic detrimental impacts on kidney function in the context of aging ( 2.2 Klotho levels decreased Klotho, a membrane-bound protein predominantly found in the kidney, was discovered over 20 years ago for its role as an antagonist of cellular aging

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[DOI] [PubMed] [Google Scholar] Chaouch S., Queval G., Vanderauwera S., Vandorpe M., Langlois-Meurinne M., Van Breusegem F., Saindrenan P., Noctor G