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Senescence: a DNA damage response and its role in aging and neurodegenerative diseases

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Activation of mTOR in senescent cells contributes to cellular dysfunction and the pro-inflammatory SASP.134 Inhibition of mTOR has been shown to reduce the expression of SASP factors and improve tissue function in animal models of aging.135 Modulation of the SASP: Senescent cells secrete a variety of pro-inflammatory cytokines, chemokines, growth factors, and proteases collectively known as the SASP