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However, users recovering from long-term or severe injuries may choose to reduce dosing gradually—for example: Week 1–4: 500mcg/day Week 5: 250mcg/day Week 6: 250mcg every other day This mild tapering strategy may help the body normalize while preserving healing momentum, especially when transitioning into maintenance supplements like collagen, MSM, or glutathione

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Metabolism 1987;36:896-9