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CIR is an independent scientific review body with FDA and consumer advocacy involvement as observers throughout the process, published in a peer-reviewed journal, but it's a separate mechanism from government drug approval

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The observation of some binding and polyubiquitylation of AGO2 complexes containing truncated miRNAs suggested that similar complexes containing naturally truncated miRNAs (presumably resulting from extensive 3′-exonucleolytic trimming) might also be susceptible to ZSWIM8-dependent degradation in cells