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Damage to mitochondrial DNA results in loss of mitochondrial membrane potential, impairment in the electron transport chain, and drives the immune and inflammatory responses (Liu and Chen, 2017), (Figure 3)
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Since the first report on the expression pattern of ZIPs and ZnTs in adipose tissue, it has become apparent that the biology of the different fat depots, namely subcutaneous and visceral fat (VAT), correlate to different expression levels of zinc-transporting proteins (255)