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doi: 10.1111/j.1365-2567.2007.02687.x 504 HummelenRChangaluchaJButamanyaNLKoyamaTECookAHabbemaJDFet al
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Inherited mutations in telomerase components ( TERT, TERC, DKC1, NHP2, NOP10, WRAP53 ) or telomere-binding proteins, which were proven to have essential telomere-protecting functions ( CTC1, POT1, TINF2, RTEL1, TPP1 ), compromise telomere maintenance, leading to progressive telomere shortening and loss of chromosomal end protection ( While inherited upregulation of telomerase has been implicated in increased risk of some cancers, environmental influences preventing telomere attrition, such as lower psychological stress, non-smoking, and exercise, have been demonstrated to render the opposite effect on cancer development ( Experimental model systems provide additional evidence that telomere erosion is a primary driver of aging