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According to Couture Med Spa, citing a New England Journal of Medicine trial, tirzepatide users can lose up to 15% of their body weight over 18 months, a result the practice attributes to the peptide's dual action on GIP and GLP-1 receptors

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Dysbiosis, defined as an imbalance in the composition of the microbiome, can lead to the overproduction of harmful substances, e.g., ammonia, which can accumulate in the brain and disrupt mitochondrial activity [218,219]